Tag Archive: vaccine


CD4 Count

It’s took me 3 weeks since my blood sample was extracted for CD4 count to pay H4 a visit to claim the result (and at the same time refill my AZT+3ZT and EFV supply). I was partial happy and disappointed with my most recent count after being on my ARV treatment since October 2011:

May 2010 – 424
February 2011 – 366
August 2011 – 97
May 2012 – 198

There you go. 198. up by 101 from more than six months ago. I’m happy that it went up as it’s a sign that the medication is working. I’m quite disappointed though that my CD4 count didn’t go up as I’ve expected. My lifestyle is to be blamed for this. I haven’t cut down on my smoking and have started consuming alcohol. Wasn’t even taking multivitamins as my doctors prescribe. Although I get ample rest (8-10 hours per day), my sleeping pattern is still incorrect staying up until the wee-morning hours for the sake of going out on dates or chilling out with my friends. I now resolve to correct these unhealthy habits and work on improving my health.

Dra. A is quite happy that the medication is working for me. She explained during my consultation that the count actually varies on a person to person basis and depending on our lifestyle. She reiterated that I need to work on targeting having more than 1,000+ CD4 count. Given that my count is still below 200, she prescribed that I take cotrimoxazole as prophylaxis against pneumonia M-W-F until my count surpasses the borderline level of 350.  She also reminded me to have pneumonia shots every six months and get annual flu vaccination.

New AIDS Discovery

US researchers have discovered two powerful antibodies that neutralise more than 90 per cent of all known strains of the HIV virus in the lab, new research released Thursday showed.

NIH-led scientists discovered the antibodies known as VRCO1 and VRCO2 that prevent most HIV strains from infecting human cells. The find is a potential breakthrough for advancing HIV vaccine design, and antibody therapy for other diseases.

The authors, whose work is published in the July 9 issue of Science, also were able to demonstrate how one of these disease-fighting proteins gets the job done.

‘The discovery of these exceptionally broadly neutralising antibodies to HIV and the structural analysis that explains how they work are exciting advances that will accelerate our efforts to find a preventive HIV vaccine for global use,’ said Dr Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health.

‘In addition, the technique the teams used to find the new antibodies represents a novel strategy that could be applied to vaccine design for many other infectious diseases,’ Fauci stressed in a statement.

The team of virologists found that the two antibodies were produced naturally and found in the blood of HIV-positive people.

They were able to isolate these antibodies using a new molecular device they developed. It zeroes in on specific cells that make antibodies against HIV. The device is an HIV protein scientists modified to react only with antibodies specific to the site where the virus binds to cells it infects.

Leading two research teams were NIAID scientists Peter Kwong, PhD, John Mascola, MD, and Gary Nabel, MD, PhD.

‘We have used our knowledge of the structure of a virus – in this case, the outer surface of HIV – to refine molecular tools that pinpoint the vulnerable spot on the virus and guide us to antibodies that attach to this spot, blocking the virus from infecting cells,’ explained Nabel.

Mascola added that: ‘the antibodies attach to a virtually unchanging part of the virus, and this explains why they can neutralise such an extraordinary range of HIV strains.’

Article reposted from: http://bigpondnews.com/articles/World/2010/07/09/New_AIDS_discovery_482654.html